Refining the Clinical Features of Serotonin Syndrome: A Prospective Observational Study of 45 Patients.

ABSTRACT:

Introduction

Serotonin syndrome (SS) is a drug-induced clinical syndrome that results from the excess intrasynaptic concentration of serotonin. Prospective observations are limited for SS.

Methods

We prospectively recruited 45 consecutive adult patients (>18 years) fulfilling the Hunter's criteria for SS. All patients were subjected to a detailed clinical history and examinations. Patients were subjected to appropriate investigations to find out the other causes. The causation of SS to serotonergic drugs was assessed according to Naranjo adverse drug reaction probability scale.

Results

The mean age was 37.3 years (range: 18-59 years). Sixty-two percent of patients were male. There were 15 different underlying clinical syndromes for which serotonergic drugs were starte

SUBMITTER: Prakash S 

PROVIDER: S-EPMC6327697 | biostudies-literature | 2019 Jan-Mar

REPOSITORIES: biostudies-literature