Human Platelet Protein Ubiquitylation and Changes following GPVI Activation.

ABSTRACT: Platelet activators stimulate post-translational modification of signalling proteins to change their activity or their molecular interactions leading to signal propagation. One covalent modification is attachment of the small protein ubiquitin to lysine residues in target proteins. Modification by ubiquitin can either target proteins for degradation by the proteasome or act as a scaffold for other proteins. Pharmacological inhibition of deubiquitylases or the proteasome inhibition of platelet activation by collagen, demonstrating a role for ubiquitylation, but relatively few substrates for ubiquitin have been identified and the molecular basis of inhibition is not established. Here, we report the ubiquitome of human platelets and changes in ubiquitylated proteins following stimulation by c

SUBMITTER: Unsworth AJ 

PROVIDER: S-EPMC6327716 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature