Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4⁺ T-cell development and allergic airway disease.

ABSTRACT:

Background

GTPase of immunity-associated protein 5 (GIMAP5) is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 single nucleotide polymorphisms have been linked to an increased risk for asthma, whereas loss of Gimap5 in mice has been associated with severe CD4⁺ T cell-driven immune pathology.

Objective

We sought to identify the molecular and cellular mechanisms by which Gimap5 deficiency predisposes to allergic airway disease.

Methods

CD4⁺ T-cell polarization and development of pathogenic CD4⁺ T cells were assessed in Gimap5-deficient mice and a human patient with a GIMAP5 loss-of-function (LOF) mutation. House dust mite-induced airway inflammation was assessed by using a complete Gimap5 LOF (Gimap5^sph/sph

SUBMITTER: Patterson AR 

PROVIDER: S-EPMC6327968 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature