Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes.

ABSTRACT:

Background

Metformin reduces plasma glucose and has been shown to increase glucagon-like peptide 1 (GLP-1) secretion. Whether this is a direct action of metformin on GLP-1 release, and whether some of the glucose-lowering effect of metformin occurs due to GLP-1 release, is unknown. The current study investigated metformin-induced GLP-1 secretion and its contribution to the overall glucose-lowering effect of metformin and underlying mechanisms in patients with type 2 diabetes.

Methods

Twelve patients with type 2 diabetes were included in this placebo-controlled, double-blinded study. On 4 separate days, the patients received metformin (1,500 mg) or placebo suspended in a liquid meal, with subsequent i.v. infusion of the GLP-1 receptor antagonist exendin9-39 (Ex9-39) or saline

SUBMITTER: Bahne E 

PROVIDER: S-EPMC6328020 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature