Early treatment of acute hepatitis C infection is cost-effective in HIV-infected men-who-have-sex-with-men.

ABSTRACT:

Background

Treatment of hepatitis C virus infections (HCV) with direct acting antivirals (DAA) can prevent new infections since cured individuals cannot transmit HCV. However, as DAAs are expensive, many countries defer treatment to advances stages of fibrosis, which results in ongoing transmission. We assessed the epidemiological impact and cost-effectiveness of treatment initiation in different stages of infection in the Netherlands where the epidemic is mainly concentrated among HIV-infected MSMs.

Methods

We calibrated a deterministic mathematical model to the Dutch HCV epidemic among HIV-infected MSM to compare three different DAA treatment scenarios: 1) immediate treatment, 2) treatment delayed to chronic infection allowing spontaneous clearance to occur, 3) treatment d

SUBMITTER: Popping S 

PROVIDER: S-EPMC6328146 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature