Blood inflammatory and endothelial markers in women with von Willebrand disease.

ABSTRACT:

Introduction

VWD-affected females often experience menorrhagia. Periodical fluctuations of the sex steroids during the menstrual cycle cause changes both in the coagulation and immune system. The aim of the current study was to assess the changes in selected inflammatory and endothelial markers in women with VWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with corresponding data from healthy controls.

Materials and methods

The study group included 12 VWD-affected females with regular menstrual cycle, with none of them being prescribed hormone treatment. They were not pregnant or breastfeeding. The control group consisted of 102 healthy females, matched for age and BMI.

Results

Within the VWD group, endostatin was higher during th

SUBMITTER: Govorov I 

PROVIDER: S-EPMC6328189 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature