Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress.

ABSTRACT: Stress profoundly impacts the brain and increases the risk of developing a psychiatric disorder. The brain's response to stress is mediated by a number of pathways that affect gene expression and protein function throughout the cell. Understanding how stress achieves such dramatic effects on the brain requires an understanding of the brain's stress response pathways. The majority of studies focused on molecular changes have employed repeated or chronic stress paradigms to assess the long-term consequences of stress and have not taken an integrative genomic and/or proteomic approach. Here, we determined the lasting impact of a single stressful event (restraint) on the broad molecular profile of the basolateral amygdala complex (BLC), a key brain region mediating emotion, memory and stress.

SUBMITTER: Sillivan SE 

PROVIDER: S-EPMC6328204 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature