Treatment of Sleep Disturbance May Reduce the Risk of Future Probable Alzheimer's Disease.

ABSTRACT:

Objective

This study explored two research questions: (a) Does sleep medication neutralize or provide a protective effect against the hazard of Alzheimer's disease (AD)? (b) Do apolipoprotein (APOE) e4 carriers reporting a sleep disturbance experience an increased risk of AD?

Method

This study is a secondary analysis of the National Alzheimer's Coordinating Center's Uniform Data Set ( n = 6,782) using Cox proportional hazards regression.

Results

Sleep disturbance was significantly associated with eventual AD development. Among the subset of participants taking general sleep medications, no relationship between sleep disturbance and eventual AD was observed. Among individuals not taking sleep medications, the increased hazard between the two variables remained. Among A

SUBMITTER: Burke SL 

PROVIDER: S-EPMC6328323 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature