Maternal Adiposity Influences Neonatal Brain Functional Connectivity.

ABSTRACT: The neural mechanisms associated with obesity have been extensively studied, but the impact of maternal obesity on fetal and neonatal brain development remains poorly understood. In this study of full-term neonates, we aimed to detect potential neonatal functional connectivity alterations associated with maternal adiposity, quantified via body-mass-index (BMI) and body-fat-mass (BFM) percentage, based on seed-based and graph theoretical analysis using resting-state fMRI data. Our results revealed significant neonatal functional connectivity alterations in all four functional domains that are implicated in adult obesity: sensory cue processing, reward processing, cognitive control, and motor control. Moreover, some of the detected areas showing regional functional connectivity alterations a

SUBMITTER: Salzwedel AP 

PROVIDER: S-EPMC6328446 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature