Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4⁺Foxp3⁺ induced Treg cells in vitro and in vivo periphery in autoimmune diseases.

ABSTRACT: Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Increasing evidence suggests that thymus-derived, natural regulatory T cells (nTreg) express a remarkably high level of TNF Receptor 2 (TNFR2) and TNFα modulates the number or function of nTreg via TNFR2 in autoimmune diseases. Nonetheless, Treg cells consist of at least nTreg and iTreg that are induced in the periphery or in vitro and two subsets may have different biological characteristics. However, the role of TNF-TNFR signaling in development and function of these iTreg cells is less clear. In this study, we systemically studied the effect of TNFα and its receptor signals on iTreg differentiation, proliferation, and function in vitro and in vivo. We further investig

SUBMITTER: Yang S 

PROVIDER: S-EPMC6328545 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature