Revisiting dispersible milk-drug tablets as a solid lipid formulation in the context of digestion.

ABSTRACT: Oral delivery of dispersible tablets is a preferred route of administration for paediatrics due to ease of administration and dose control. Milk has gained interest as a drug delivery system due to its ability to dissolve poorly water-soluble drugs. There are no reports of milk tablet formulations being assessed in the context of lipid digestion, which is critical in influencing orally administered drug solubility and bioavailability. Milk-drug tablets were formulated by blending freeze-dried bovine milk or infant formula with the poorly water-soluble drug cinnarizine, which were directly compressed. Tablet strength, friability and dispersibility were quantified and synchrotron X-ray scattering was used to determine the lipid liquid crystalline phases formed during in vitro digestion of di

SUBMITTER: Binte Abu Bakar SY 

PROVIDER: S-EPMC6328708 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature