Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy.

ABSTRACT: Women with early-stage breast cancer have reduced peak exercise oxygen uptake (peak VO₂ ). The purpose of this study was to evaluate peak VO₂ and right (RV) and left (LV) ventricular function prior to adjuvant chemotherapy. Twenty-nine early-stage breast cancer patients (mean age: 48 years) and 10 age-matched healthy women were studied. Participants performed an upright cycle exercise test with expired gas analysis to measure peak VO₂ . RV and LV volumes and function were measured at rest, submaximal and peak supine cycle exercise using cardiac magnetic resonance imaging. Peak VO₂ was significantly lower in breast cancer patients versus controls (1.7 ± 0.4 vs. 2.3 ± 0.5 L/min, P = 0.0013; 25 ± 6 vs. 35 ± 6 mL/kg/min, P = 0.00009). No significant

SUBMITTER: Beaudry RI 

PROVIDER: S-EPMC6328913 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature