Clazakizumab in late antibody-mediated rejection: study protocol of a randomized controlled pilot trial.

ABSTRACT:

Background

Late antibody-mediated rejection (ABMR) triggered by donor-specific antibodies (DSA) is a cardinal cause of kidney allograft dysfunction and loss. Diagnostic criteria for this rejection type are well established, but effective treatment remains a major challenge. Recent randomized controlled trials (RCT) have failed to demonstrate the efficacy of widely used therapies, such as rituximab plus intravenous immunoglobulin or proteasome inhibition (bortezomib), reinforcing a great need for new therapeutic concepts. One promising target in this context may be interleukin-6 (IL-6), a pleiotropic cytokine known to play an important role in inflammation and adaptive immunity.

Methods

This investigator-driven RCT was designed to assess the safety and efficacy of clazakizuma

SUBMITTER: Eskandary F 

PROVIDER: S-EPMC6329051 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature