Infection risk among adults with down syndrome: a two group series of 101 patients in a tertiary center.

ABSTRACT:

Background

Down syndrome (DS) is the most common form of viable chromosomal abnormality. DS is associated with recurrent infections, auto-immunity and malignancies in children. Little is known about immunity and infections in DS at adulthood.

Methods

We studied two separate group of adults (> 18 years old) with DS in a single referral tertiary center (Strasbourg University Hospital). The first group included 37 ambulatory DS patients between November 2014 and May 2017. We analyzed exhaustive serological and immunobiological parameters, at one point, together with the prevalence of infections, autoimmune manifestations and malignancies. The second group included 64 hospitalized patients (138 stays) in the same center, between January 2005 and December 2016.

Results

One

SUBMITTER: Guffroy A 

PROVIDER: S-EPMC6329099 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature