Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review.

ABSTRACT:

Background

Exhaled biomarkers may be related to disease processes in idiopathic pulmonary fibrosis (IPF) however their clinical role remains unclear. We performed a systematic review to investigate whether breath biomarkers discriminate between patients with IPF and healthy controls. We also assessed correlation with lung function, ability to distinguish diagnostic subgroups and change in response to treatment.

Methods

MEDLINE, EMBASE and Web of Science databases were searched. Study selection was limited to adults with a diagnosis of IPF as per international guidelines.

Results

Of 1014 studies screened, fourteen fulfilled selection criteria and included 257 IPF patients. Twenty individual biomarkers discriminated between IPF and controls and four showed correlation w

SUBMITTER: Hayton C 

PROVIDER: S-EPMC6329167 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature