Impact of uteroplacental insufficiency on ovarian follicular pool in the rat.

ABSTRACT:

Background

A low oxygen supply to the fetus causes intrauterine growth restriction and can affect gonadal development of the offspring, having a potential impact on fertility. We investigated histology and gene expression in the postnatal rat ovary after fetal hypoxia induced by uterine artery ligation.

Methods

Sprague-Dawley rats underwent uterine artery ligation at day 19 of gestation. Offspring were sacrificed at 5, 20 and 40 days post-partum. Follicles were counted and classified in hematoxylin-eosin stained sections. Gene expression of 90 genes was analyzed by TaqMan® Low Density Array.

Results

A significantly lower number of total and primordial follicles was detected in 20 days post-partum intrauterine growth restricted animals. Follicle density was not differe

SUBMITTER: Pampanini V 

PROVIDER: S-EPMC6329190 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature