Ontology highlight
ABSTRACT:
SUBMITTER: Nakaoku T
PROVIDER: S-EPMC6329293 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Clinical cancer research : an official journal of the American Association for Cancer Research 20140411 12
<h4>Purpose</h4>To identify druggable oncogenic fusions in invasive mucinous adenocarcinoma (IMA) of the lung, a malignant type of lung adenocarcinoma in which KRAS mutations frequently occur.<h4>Experimental design</h4>From an IMA cohort of 90 cases, consisting of 56 cases (62%) with KRAS mutations and 34 cases without (38%), we conducted whole-transcriptome sequencing of 32 IMAs, including 27 cases without KRAS mutations. We used the sequencing data to identify gene fusions, and then performed ...[more]