Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

ABSTRACT: In the present study, aiming to identify loci associated with osteoporosis, we conducted a joint association study of 2 independent genome-wide association meta-analyses of femoral neck and lumbar spine bone mineral densities (BMDs): 1) an in-house study of 6 samples involving 7484 subjects, and 2) the GEFOS-seq study of 7 samples involving 32,965 subjects. The in-house samples were imputed by the 1000 genomes project phase 3 reference panel. SNP-based association test was applied to 7,998,108 autosomal SNPs in each meta-analysis, and for each SNP the 2 association signals were then combined for joint analysis and for mutual replication. Combining the evidence from both studies, we identified 2 novel loci associated with BMDs at the genome-wide significance level (α=5.0×10^-8): 2

SUBMITTER: Pei YF 

PROVIDER: S-EPMC6329308 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature