Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments.

ABSTRACT:

Introduction

The placenta produces microRNAs (miRNA) that may traffic to the maternal or fetal compartments and influence the physiology of pregnancy. The trafficking patterns of miRNA expressed from the large human chromosome 19 and chromosome 14 clusters (C19MC and C14MC), remains unclear. We interrogated the cross-sectional landscape of miRNA expression within the human placenta, fetal and maternal plasma to elucidate miRNA trafficking. We hypothesized that C19MC and C14MC miRNAs have similar expression patterns across the maternal-fetal compartments.

Methods

Placental biopsies, maternal and fetal venous plasma were collected from 25 pregnancies, and RNA was quantified using next generation sequencing. We identified expression and correlations differences among the compar

SUBMITTER: Paquette AG 

PROVIDER: S-EPMC6329371 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature