The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry.

ABSTRACT: Interferons (IFNs) mediate cellular defence against viral pathogens by upregulation of IFN-stimulated genes whose products interact with viral components or alter cellular physiology to suppress viral replication^1-3. Among the IFN-stimulated genes that can inhibit influenza A virus (IAV)⁴ are the myxovirus resistance 1 GTPase⁵ and IFN-induced transmembrane protein 3 (refs ^6,7). Here, we use ectopic expression and gene knockout to demonstrate that the IFN-inducible 219-amino acid short isoform of human nuclear receptor coactivator 7 (NCOA7) is an inhibitor of IAV as well as other viruses that enter the cell by endocytosis, including hepatitis C virus. NCOA7 interacts with the vacuolar H⁺-ATPase (V-ATPase) and its expression promotes cyt

SUBMITTER: Doyle T 

PROVIDER: S-EPMC6329445 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature