Risk factors for mortality after respiratory syncytial virus lower respiratory tract infection in adults with hematologic malignancies.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) is associated with high mortality in patients with hematologic malignancies (HM). We sought to determine whether allogeneic hematopoietic cell transplant (allo-HCT) recipients would be at higher risk for 60-day mortality.

Methods

We examined a retrospective cohort of adults with HM with or without HCT treated for RSV LRTI (n = 154) at our institution from 1996-2013. We defined possible RSV LRTI as RSV detected only in the upper respiratory tract with new radiologic infiltrates and proven RSV LRTI as RSV detected in BAL fluid with new radiologic infiltrates. Immunodeficiency Scoring Index (ISI) and Severe Immunodeficiency (SID) criteria were calculated for HCT recipients. Multivariable logis

SUBMITTER: Vakil E 

PROVIDER: S-EPMC6329612 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature