Large artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT study.

ABSTRACT:

Objectives

The cardiotonic steroid, marinobufagenin (MBG), has been shown to play a physiological natriuretic role in response to salt intake. However, recent studies in clinical and animal models demonstrated possible links between elevated levels of endogenous MBG and increased arterial stiffness. Large artery stiffness is a known predictor of future cardiovascular disease. We, therefore, investigated whether large artery stiffness relates to 24-h urinary MBG excretion in young apparently healthy black and white adults.

Methods

This study included data of 711 participants (black 51%, men 42%, mean age 24.8 ± 3.02 years). We measured the carotid-femoral pulse wave velocity (cfPWV), 24-h urinary MBG and sodium excretion.

Results

In single, partial and multivariable ad

SUBMITTER: Strauss M 

PROVIDER: S-EPMC6329631 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature