Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's disease.

ABSTRACT:

Background and purpose

Dementia in Parkinson's disease (PD) is common and disabling. Identification of modifiable risk factors for it is essential. Vascular risk factors (VRFs) may be associated with cognitive decline in early PD. Biomarkers that serve as surrogates of the long-term effect of VRFs on PD are needed. To that end, we aimed to quantitate white matter hyperintensities (WMH) in early PD, measure associations with VRFs and examine relationships between WMH and longitudinal cognition.

Methods

Participants in the Parkinson's Progression Markers Initiative study (141 patients with PD, 63 healthy controls) with adequate baseline structural brain magnetic resonance imaging data were included. Hypertension and diabetes history, and body mass index were combined to create

SUBMITTER: Chahine LM 

PROVIDER: S-EPMC6329649 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature