Differences in patterns of care and outcomes between grade II and grade III molecularly defined 1p19q co-deleted gliomas.

ABSTRACT: Molecular markers are redefining classification of lower grade gliomas and ushering in a paradigm shift in their management. Our objective was to evaluate the differences in pattern of care and outcome by comparing grade II and grade III molecularly defined 1p19q co-deleted gliomas. We evaluated 1618 patients in the National Cancer Database diagnosed with 1p19q co-deleted gliomas from 2010 through 2014 and treated with surgery followed by radiation therapy (RT), chemotherapy (CT), or combined-modality therapy. Differences in patterns of care included that fifty-one percent of grade II tumors received surgery alone, whereas most patients with grade III tumors (86%) received surgery or biopsy followed by a form of post-operative therapy (p < 0.001). In a propensity score matched cohor

SUBMITTER: Yeboa DN 

PROVIDER: S-EPMC6329703 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature