Ontology highlight
ABSTRACT:
SUBMITTER: Herber CB
PROVIDER: S-EPMC6329772 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature communications 20190111 1
Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in females. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported mouse models. Stereotaxic guided deletion of ERα in the arcuate nucleus increases bone mass in intact and o ...[more]