Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers.

ABSTRACT: OBJECTIVE:This double-blind, placebo controlled study examined whether menthol inhaled from an electronic cigarette (e-cigarette) would change subjective and withdrawal alleviating effects of intravenous nicotine in young adult smokers. METHODS:A total of 32 menthol-preferring smokers and 25 non-menthol-preferring smokers participated in the study that consisted of a random sequence of three different inhaled menthol conditions (0.0%, 0.5%, and 3.2%) across three test sessions (a single menthol condition per session). In each test session (performed at least 24 hours apart), a random order of saline, and two different nicotine infusions of 0.25 mg and 0.5 mg/70 kg of bodyweight were administered, one hour apart, concurrent with menthol inhalation. RESULTS:While menthol did not alter the po

SUBMITTER: Valentine GW 

PROVIDER: S-EPMC6329876 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature