Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies.

ABSTRACT: Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Levels of five and four pollutants were measured, respectively, using personal exposure monitoring devices. Serum samples were used for metabolomic profiling. The association between TRAP and levels of each metabolic feature was assessed. All pollutant levels were significantly higher at the hig

SUBMITTER: van Veldhoven K 

PROVIDER: S-EPMC6329888 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature