MetaboRank: network-based recommendation system to interpret and enrich metabolomics results.

ABSTRACT:

Motivation

Metabolomics has shown great potential to improve the understanding of complex diseases, potentially leading to therapeutic target identification. However, no single analytical method allows monitoring all metabolites in a sample, resulting in incomplete metabolic fingerprints. This incompleteness constitutes a stumbling block to interpretation, raising the need for methods that can enrich those fingerprints. We propose MetaboRank, a new solution inspired by social network recommendation systems for the identification of metabolites potentially related to a metabolic fingerprint.

Results

MetaboRank method had been used to enrich metabolomics data obtained on cerebrospinal fluid samples from patients suffering from hepatic encephalopathy (HE). MetaboRank successful

SUBMITTER: Frainay C 

PROVIDER: S-EPMC6330003 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature