Flux tope analysis: studying the coordination of reaction directions in metabolic networks.

ABSTRACT:

Motivation

Elementary flux mode (EFM) analysis allows an unbiased description of metabolic networks in terms of minimal pathways (involving a minimal set of reactions). To date, the enumeration of EFMs is impracticable in genome-scale metabolic models. In a complementary approach, we introduce the concept of a flux tope (FT), involving a maximal set of reactions (with fixed directions), which allows one to study the coordination of reaction directions in metabolic networks and opens a new way for EFM enumeration.

Results

A FT is a (nontrivial) subset of the flux cone specified by fixing the directions of all reversible reactions. In a consistent metabolic network (without unused reactions), every FT contains a 'maximal pathway', carrying flux in all reactions. This decomposi

SUBMITTER: Gerstl MP 

PROVIDER: S-EPMC6330010 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature