Ontology highlight
ABSTRACT:
SUBMITTER: Hartley AM
PROVIDER: S-EPMC6330080 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20181231 1
Cytochrome c oxidase (complex IV, CIV) is known in mammals to exist independently or in association with other respiratory proteins to form supercomplexes (SCs). In Saccharomyces cerevisiae, CIV is found solely in an SC with cytochrome bc<sub>1</sub> (complex III, CIII). Here, we present the cryogenic electron microscopy (cryo-EM) structure of S. cerevisiae CIV in a III<sub>2</sub>IV<sub>2</sub> SC at 3.3 Å resolution. While overall similarity to mammalian homologs is high, we found notable diff ...[more]