Simultaneous Evaluation of Lung Anatomy and Ventilation Using 4D Respiratory-Motion-Resolved Ultrashort Echo Time Sparse MRI.

ABSTRACT:

Background

Computed tomography (CT) and spirometry are the current standard methods for assessing lung anatomy and pulmonary ventilation, respectively. However, CT provides limited ventilation information and spirometry only provides global measures of lung ventilation. Thus, a method that can enable simultaneous examination of lung anatomy and ventilation is of clinical interest.

Purpose

To develop and test a 4D respiratory-resolved sparse lung MRI (XD-UTE: eXtra-Dimensional Ultrashort TE imaging) approach for simultaneous evaluation of lung anatomy and pulmonary ventilation.

Study type

Prospective.

Population

In all, 23 subjects (11 volunteers and 12 patients, mean age = 63.6 ± 8.4).

Field strength/sequence

3T MR; a prototype 3D golden-angle radial UTE

SUBMITTER: Feng L 

PROVIDER: S-EPMC6330120 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature