Differential cerebral hemometabolic responses to blood transfusions in adults and children with sickle cell anemia.

ABSTRACT:

Background

Blood transfusions are administered to children and adults with sickle cell anemia (SCA) for secondary stroke prevention, or as treatment for recurrent pain crises or acute anemia, but transfusion effects on cerebral hemodynamics and metabolism are not well-characterized.

Purpose

To compare blood transfusion-induced changes in hemometabolic parameters, including oxygen extraction fraction (OEF) and cerebral blood flow (CBF), within and between adults and children with SCA.

Study type

Prospective, longitudinal study.

Subjects

Adults with SCA (n = 16) receiving simple (n = 7) or exchange (n = 9) transfusions and children with SCA (n = 11) receiving exchange transfusions were scanned once when hematocrit was near nadir and again within 7 days of transfu

SUBMITTER: Juttukonda MR 

PROVIDER: S-EPMC6330124 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature