Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study.

ABSTRACT: Several genome-wide association studies (GWAS) have identified genetic variants associated with birth weight. To date, however, most GWAS of birth weight have focused primarily on European ancestry samples even though prevalence of low birth weight is higher among African-Americans. We conducted admixture mapping using 2918 ancestral informative markers in 2596 participants of the Black Women's Health Study, with the goal of identifying novel genomic regions where local African ancestry is associated with birth weight. In addition, we performed a replication analysis of 11 previously identified index single nucleotide polymorphisms (SNPs), and fine-mapped those genetic loci to identify better or new genetic variants associated with birth weight in African-Americans. We found that high Afri

SUBMITTER: Ochs-Balcom HM 

PROVIDER: S-EPMC6330255 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature