Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa.

ABSTRACT: Pseudomonas aeruginosa is known as an opportunistic pathogen that often causes persistent infections associated with high level of antibiotic-resistance and biofilms formation. Chemical interference with bacterial cell-to-cell communication, termed quorum sensing (QS), has been recognized as an attractive approach to control infections and address the drug resistance problems currently observed worldwide. Instead of imposing direct selective pressure on bacterial growth, the right bioactive compounds can preferentially block QS-based communication and attenuate cascades of bacterial gene expression and production of virulence factors, thus leading to reduced pathogenicity. Herein, we report on the potential of itaconimides as quorum sensing inhibitors (QSI) of P. aeruginosa.

SUBMITTER: Fong J 

PROVIDER: S-EPMC6330316 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature