Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients.

ABSTRACT:

Introduction

Mood disorder patients have a tendency to be more internally oriented, with difficulties in switching attentional focus, which might result in the generation of negative thoughts, such as rumination. The present study explored self-referential neural activity correlating with rumination tendency and attentional switching capacity in bipolar disorder.

Methods

Twenty euthymic bipolar patients and twenty matched healthy controls underwent a novel introspection task of switching between internally and externally focused attention during a word processing task, while their brain activity was assessed using functional MRI.

Results

During internal focus, higher activity in self-related regions (mPFC, PCC) was found in euthymic bipolar patients as compared to con

SUBMITTER: Apazoglou K 

PROVIDER: S-EPMC6330377 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature