The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis.

ABSTRACT:

Background

Until now, there is no effective anti-fibrotic therapy available for liver cirrhosis. Stem cell therapies have been studied for the treatment of hepatic fibrosis. However, the use of embryonic stem cells or induced pluripotent stem cells (iPSC) has limitations such as ethical concern or malignancy potential. Induced hepatocyte-like cells (iHEPs) generated by direct reprogramming technology may overcome these limitations.

Methods

In this study, we generated iHEPs by direct reprogramming from mouse embryonic fibroblast (MEF) either using specific transcription factors such as c-Myc and Klf-4 (type A), or adding small molecules to HNF1α (type B).

Results

We investigated the effect of iHEPs on acute liver injury and chronic hepatic fibrosis animal models induce

SUBMITTER: Park S 

PROVIDER: S-EPMC6330392 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature