Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response.

ABSTRACT:

Background

Substantial numbers of neonates with hypoxic respiratory failure (HRF) do not immediately respond to inhaled nitric oxide (iNO) and are often labeled as non-responders. This retrospective data analysis assessed time to treatment response in the iNO key registration trial.

Methods

Treatment response was defined as a ≥10% increase in partial pressure of arterial oxygen (PaO₂) or a ≥10% decrease in oxygenation index (OI) after initiation of study gas without the need for extracorporeal membrane oxygenation (ECMO). The proportion of patients showing a response at 30 min, 1 h, 24 h, and >24 h after iNO or placebo initiation was calculated and stratified by baseline PaO₂ and OI.

Results

Data from 248 patients (iNO: n = 126; placebo: n = 122)

SUBMITTER: Nelin LD 

PROVIDER: S-EPMC6330425 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature