Characteristics of T cell receptor repertoires of patients with acute myocardial infarction through high-throughput sequencing.

ABSTRACT:

Background

T cells are key regulators of immunity and one of the cells recruited in atherosclerosis and participated in various stages of the development of atherosclerosis. Characterizing T-cell receptor (TCR) repertoires is a priority of great scientific interest and potential clinical utility for the early diagnosis, risk stratification and prognostic evaluation of acute myocardial infarction (AMI).

Methods

The TCR repertoires in 21 subjects including 7 patients with non-ST-segment elevation myocardial infarction (NSTEMI), 6 patients with ST-segment elevation myocardial infarction (STEMI) and 8 subjects with normal coronary artery (NCA) as control were characterized by using high-throughput sequencing. Bioinformatics analysis were performed.

Results

Patients with N

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC6330436 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature