Serum uric acid and cardiovascular mortality in chronic kidney disease: a meta-analysis.

ABSTRACT:

Background

Conflicting results have been reported from studies evaluating serum uric acid (SUA) levels as an independent risk factor for cardiovascular mortality in patients with chronic kidney disease (CKD).

Methods

We systematically searched MEDLINE, Web of Science, and bibliographies of retrieved articles to identify studies reporting on the association between SUA levels and cardiovascular mortality in patients with CKD. Random-effects models were used to calculate the pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI).

Results

We included 11 studies with an overall sample of 27,081 patients with CKD in this meta-analysis. By meta-analysis, restricted to 7 studies (n = 11,050), patients with the highest SUA were associated with an increased

SUBMITTER: Luo Q 

PROVIDER: S-EPMC6330757 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature