Liver damage indices as a tool for modifying methadone maintenance treatment: a cross-sectional study.

ABSTRACT:

Aim

To assess the effect of liver damage on methadone metabolism in opiate addicts undergoing methadone maintenance treatment (MMT).

Methods

This cross-sectional study recruited 74 patients treated at the outpatient clinic of Public Health Institute of Split-Dalmatia County from 2013-2016. Concentrations of methadone and its main inactive metabolite were measured in participants' biological samples on regular check-ups. Urine samples obtained before oral methadone intake, and blood and urine samples obtained 90 minutes after methadone intake were analyzed using gas chromatography/mass spectrometry. Participants were divided into groups according to liver damage criteria: hepatitis C virus status (positive, negative, or clinical remission); aspartate aminotransferase to plate

SUBMITTER: Kljucevic Z 

PROVIDER: S-EPMC6330771 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature