Label-free quantitative proteomic analysis reveals potential biomarkers for early healing in cutaneous leishmaniasis.

ABSTRACT:

Background

Leishmaniasis is a parasitic disease caused by more than 20 species of the Leishmania genus. The disease is globally distributed and is endemic in 97 countries and three territories in the tropical and subtropical regions. The efficacy of the current treatments is becoming increasingly low either due to incomplete treatment or resistant parasites. Failure of treatment is frequent, and therefore, the search for early biomarkers of therapeutic response in cutaneous leishmaniasis (CL) is urgently needed.

Objective

The aim of this study was to compare the proteomic profiles in patients with CL before and after 7 days of treatment and identify early biomarkers of curative response.

Methods

Four patients with a parasitological diagnosis of leishmaniasis wi

SUBMITTER: Montoya A 

PROVIDER: S-EPMC6330957 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature