Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers.

ABSTRACT:

Objectives

Lung adenocarcinoma in never-smokers accounts for 15-20% of all lung cancer. Although targetable mutations are more prevalent in these tumors, the biological and clinical importance of coexisting and/or mutually exclusive abnormalities is just emerging. This study evaluates the relationships between common genetic and epigenetic aberrations in these tumors.

Materials and methods

Next-generation sequencing was employed to screen 20 commonly mutated cancer-driver genes in 112 lung adenocarcinomas from never-smokers. The relationship of these mutations with cancer-related methylation of 59 genes, and geographical/ethnic differences in the prevalence for mutations compared to multiple East Asian never-smoker lung adenocarcinoma cohorts was studied.

Results

The

SUBMITTER: Tessema M 

PROVIDER: S-EPMC6331003 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature