Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

ABSTRACT: Development and routine tissue homeostasis require a high turnover of apoptotic cells. These cells are removed by professional and non-professional phagocytes via efferocytosis¹. How a phagocyte maintains its homeostasis while coordinating corpse uptake, processing ingested materials and secreting anti-inflammatory mediators is incompletely understood^1,2. Here, using RNA sequencing to characterize the transcriptional program of phagocytes actively engulfing apoptotic cells, we identify a genetic signature involving 33 members of the solute carrier (SLC) family of membrane transport proteins, in which expression is specifically modulated during efferocytosis, but not during antibody-mediated phagocytosis. We assessed the functional relevance of these SLCs in efferocyti

SUBMITTER: Morioka S 

PROVIDER: S-EPMC6331005 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature