Determinants of treatment response in first-episode psychosis: an ¹⁸F-DOPA PET study.

ABSTRACT: Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and the development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated in responders and unaltered in non-responders. We therefore aimed to test this in a prospective cohort, with a nested case-control comparison. 40 volunteers (26 patients with first-episode psychosis and 14 controls) received an ¹⁸F-DOPA Positron Emission Tomography scan to measure DSC (Ki^cer) prior to antipsychotic treatment. Clinical assessments (Positive and Negative Syndrome Scale, PANSS, and Global Assessment of Functioning, GAF) occurred at baselin

SUBMITTER: Jauhar S 

PROVIDER: S-EPMC6331038 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature