Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

ABSTRACT:

Importance

Alcohol dependence (AD) and major depression (MD) are leading causes of disability that often co-occur. Genetic epidemiologic data have shown that AD and MD share a common possible genetic cause. The molecular nature of this shared genetic basis is poorly understood.

Objectives

To detect genetic risk variants for comorbid AD and MD and to determine whether polygenic risk alleles are shared with neuropsychiatric traits or subcortical brain volumes.

Design, setting, and participants

This genome-wide association study analyzed criterion counts of comorbid AD and MD in African American and European American data sets collected as part of the Yale-Penn study of the genetics of drug and alcohol dependence from February 14, 1999, to January 13, 2015. After excludi

SUBMITTER: Zhou H 

PROVIDER: S-EPMC6331050 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature