Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis.

ABSTRACT:

Background

Giant cell tumor of bone (GCTB) is a locally aggressive tumor, and its postoperative recurrence remains a problem. The present meta-analysis aimed to analyze the effect of bisphosphonates (BPs) on local recurrence of GCTB.

Methods

Seven case-control studies were included by computerized searches of bibliographic databases (PubMed, AMED, EMBASE, the Cochrane library, ISI Web of Science, and China National Knowledge Infrastructure). The pooled adjusted ORs were calculated to evaluate the local recurrence of GCTB.

Results

The BP group presented significantly lower total local recurrence rate than the control group in GCTB (P<0.01). Subgroup analysis shows BP group presented significantly lower local recurrence than the control group in GCTB with differe

SUBMITTER: Shi M 

PROVIDER: S-EPMC6331072 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature