CDK contribution to DSB formation and recombination in fission yeast meiosis.

ABSTRACT: CDKs (cyclin-dependent kinases) associate with different cyclins to form different CDK-complexes that are fundamental for an ordered cell cycle progression, and the coordination of this progression with different aspects of the cellular physiology. During meiosis programmed DNA double-strand breaks (DSBs) initiate recombination that in addition to generating genetic variability are essential for the reductional chromosome segregation during the first meiotic division, and therefore for genome stability and viability of the gametes. However, how meiotic progression and DSB formation are coordinated, and the role CDKs have in the process, is not well understood. We have used single and double cyclin deletion mutants, and chemical inhibition of global CDK activity using the cdc2-asM17 allele,

SUBMITTER: Bustamante-Jaramillo LF 

PROVIDER: S-EPMC6331086 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature