Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence.

ABSTRACT:

Background

Lung cancer is the most common adult malignancy accounting for the largest proportion of cancer related deaths. Iron (Fe) is an essential trace element and is a component of several major metabolic pathways playing an important role in many physiological processes. In this study we evaluated the association between Fe concentration in serum, iron metabolism parameters and genetic variaton in 7 genes involved in iron metabolism and anti-oxidative processes with the incidence of lung cancer in Poland.

Materials and methods

The study included 200 lung cancer patients and 200 matched healthy control subjects. We analyzed serum iron concentration and iron metabolism parameters (TIBC, UIBC, serum ferritin and transferrin saturation), and genotyped seven variants in seve

SUBMITTER: Sukiennicki GM 

PROVIDER: S-EPMC6331102 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature