Hippocampal Place Fields Maintain a Coherent and Flexible Map across Long Timescales.

ABSTRACT: To provide a substrate for remembering where in space events have occurred, place cells must reliably encode the same positions across long timescales. However, in many cases, place cells exhibit instability by randomly reorganizing their place fields between experiences, challenging this premise. Recent evidence suggests that, in some cases, instability could also arise from coherent rotations of place fields, as well as from random reorganization. To investigate this possibility, we performed in vivo calcium imaging in dorsal hippocampal region CA1 of freely moving mice while they explored two arenas with different geometry and visual cues across 8 days. The two arenas were rotated randomly between sessions and then connected, allowing us to probe how cue rotations, the integration of ne

SUBMITTER: Kinsky NR 

PROVIDER: S-EPMC6331214 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature