Urinary oxidative stress biomarkers and accelerated time to spontaneous delivery.

ABSTRACT:

Background

Oxidative stress has been implicated in numerous birth outcomes, including spontaneous preterm birth. However, the relationship with presentation at delivery has been less well studied. We assessed the relationship between oxidative stress biomarkers and gestational duration with a focus on spontaneous presentation for delivery.

Methods

Our sample included 740 women from a multi-center prospective cohort study, recruited from 2010 to 2012. Resultant measures of oxidative stress in pregnancy prostaglandin F_2α (PGF_2α), 8-iso-prostaglandin F_2α (8-iso-PGF_2α), and the primary 8-iso-PGF_2α metabolite were measured in third trimester urine samples. Information on presentation for delivery was abstracted from medical r

SUBMITTER: Rosen EM 

PROVIDER: S-EPMC6331226 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature